Detroit won 45-21 in Glendale. Jahmyr Gibbs ran for 151 yards and two touchdowns, and the Lions scored 24 points in the second quarter. Watch Detroit Lions vs Arizona Cardinals highlights or stream on FOX One. The Week 5 game of the 2026 NFL season came from State Farm Stadium in Glendale, AZ on Sunday, Oct. 11, 2026 at 4:25 p.m. ET / 1:25 p.m. PT.

Detroit leads the series 39-28-6 across 73 meetings that go back to Nov. 22, 1931, when the Lions were still the Portsmouth Spartans, the Cardinals still played in Chicago, and Chicago won 20-19. Six of those meetings ended in ties, and the most recent is the one people remember: Kyler Murray's NFL debut on Sept. 8, 2019, at State Farm Stadium, when he threw for 308 yards and brought Arizona back from 18 points down in the fourth quarter before the teams traded field goals in overtime and settled for 27-27. Detroit won the Week 5 meeting 45-21 at State Farm Stadium on Oct. 11, 2026.