The 49ers beat Arizona 36-30. Brock Purdy threw four touchdown passes, two of them to George Kittle in the fourth quarter. Watch Arizona Cardinals vs San Francisco 49ers highlights or stream on FOX One. The Week 3 game of the 2026 NFL season came from Levi's Stadium in Santa Clara, CA on Sunday, Sept. 27, 2026 at 4:05 p.m. ET / 1:05 p.m. PT.

San Francisco leads the all-time series 39-31 and is 22-15 at home in it, an edge built almost entirely inside the past quarter century. The first meeting came on Nov. 18, 1951, when the franchise was still the Chicago Cardinals and won 27-21, but the clubs then spent decades apart, the Cardinals parked in the NFC East from 1970 through 2001. For all those games, they have never met in the postseason.