Watch Arizona Cardinals vs San Francisco 49ers live on FOX or stream the game on FOX One from Levi's Stadium in Santa Clara, CA on Sunday, Sept. 27, 2026 at 4:05 p.m. ET / 1:05 p.m. PT during NFL Week 3 of the 2026 NFL season. This is the 70th meeting between the NFC West rivals, a series that did not become a twice-a-year fixture until the 2002 realignment moved Arizona into the division. Brock Purdy opened the season 25-of-34 for 205 yards and three touchdowns, making him the first San Francisco quarterback with three passing scores in a season opener since Colin Kaepernick in 2013. Mike Evans caught one of them in his 49ers debut.

Where to Watch Arizona Cardinals vs San Francisco 49ers Live

How to Watch Cardinals vs 49ers Without Cable

San Francisco swept last season, and one of those wins came in this building by a single point, 16-15 on Sept. 21, 2025, before the 49ers turned the November rematch into a 41-22 rout. Arizona comes back without Kyler Murray, released in March after a foot injury ended his year. Mike LaFleur is the first Cardinals head coach to win his debut since Don Coryell in 1973, a 26-14 result at SoFi Stadium. You can stream Cardinals vs 49ers live on FOX One. FOX One brings together live FOX NFL games, highlights, expert coverage, and live and on-demand FOX programming, all in one place. Start your 3-day free trial and stream on supported devices.

FOX NFL Schedule 2026 — Week 3

Sunday, September 27, 2026
Week 3 — Watch Panthers vs Browns — 1:00 p.m. ET / 10:00 a.m. PT
Week 3 — Watch Chargers vs Bills — 1:00 p.m. ET / 10:00 a.m. PT
Week 3 — Watch Jets vs Lions — 1:00 p.m. ET / 10:00 a.m. PT
Week 3 — Watch Seahawks vs Commanders — 1:00 p.m. ET / 10:00 a.m. PT
Week 3 — Watch Cardinals vs 49ers — 4:05 p.m. ET / 1:05 p.m. PT
Week 3 — Watch Vikings vs Buccaneers — 4:05 p.m. ET / 1:05 p.m. PT

San Francisco leads the all-time series 38-31 and is 21-15 at home in it, an edge built almost entirely inside the past quarter century. The first meeting came on Nov. 18, 1951, when the franchise was still the Chicago Cardinals and won 27-21, but the clubs then spent decades apart, the Cardinals parked in the NFC East from 1970 through 2001. For all those games, they have never met in the postseason.