San Francisco rolled past Miami 35-13. Brock Purdy completed 20 of 22 passes, and the 49ers scored touchdowns on their first five drives. Watch Miami Dolphins vs San Francisco 49ers highlights or stream on FOX One. The Week 2 game of the 2026 NFL season came from Levi's Stadium in Santa Clara, CA on Sunday, Sept. 20, 2026 at 4:25 p.m. ET / 1:25 p.m. PT.

Miami leads the all-time series 9-7, including a 9-6 mark in regular-season play, while San Francisco is 4-4 at home against the Dolphins. The defining meeting came on Jan. 20, 1985, when the 49ers won Super Bowl XIX 38-16 at Stanford Stadium behind Joe Montana's 331 passing yards and MVP performance. It remains the only Super Bowl appearance of Dan Marino's career, and the result still shapes how the matchup is framed four decades later. San Francisco's 35-13 win in September 2026 cut Miami's all-time lead to 9-8 and put the 49ers ahead 5-4 at home in the series.