San Francisco won 32-29 in Seattle. Brock Purdy hit Brandin Cooks for a fourth-quarter touchdown, and Eddy Piñeiro's 44-yard field goal with 1:56 left put the 49ers ahead for good. Watch San Francisco 49ers vs Seattle Seahawks highlights or stream on FOX One. The Week 5 game of the 2026 NFL season came from Lumen Field in Seattle, WA on Sunday, Oct. 11, 2026 at 4:25 p.m. ET / 1:25 p.m. PT.

Seattle leads the all-time series 33-25, and most of that file has been written since the Seahawks moved into the NFC West in 2002, with the Jim Harbaugh and Pete Carroll years giving it its edge. The defining moment came at CenturyLink Field on Jan. 19, 2014, when Richard Sherman tipped Colin Kaepernick's throw into Malcolm Smith's hands in the end zone with 22 seconds left, a 23-17 NFC Championship Game win that sent Seattle to Super Bowl XLVIII. San Francisco won the Week 5 meeting 32-29 at Lumen Field on Oct. 11, 2026.