Watch Los Angeles Chargers vs Buffalo Bills live on FOX or stream the game on FOX One from Highmark Stadium in Orchard Park, NY on Sunday, Sept. 27, 2026 at 1:00 p.m. ET / 10:00 a.m. PT during NFL Week 3 of the 2026 NFL season. Buffalo and the Chargers were both there for the AFL’s opening season, and the series has run more than 60 years deep since, surviving the Chargers’ moves from Los Angeles to San Diego and back again. Buffalo opened with a 36-31 win at Houston that changed hands nine times, Josh Allen answering a 31-30 deficit with a seven-play, 96-yard drive and a 34-yard touchdown to Joshua Palmer with 1:36 left in Joe Brady’s first game as head coach.

Where to Watch Los Angeles Chargers vs Buffalo Bills Live

How to Watch Chargers vs Bills Without Cable

Buffalo has the most recent word here. The Bills won 24-22 at SoFi Stadium on Dec. 23, 2023, with Josh Allen accounting for three touchdowns and Tyler Bass hitting the game winner, and the schedule has not paired the clubs since. Jim Harbaugh called his team sloppy after the opener. The Chargers turned the ball over on downs three times in a 26-14 loss to Arizona, and Ladd McConkey, who had a team-high 82 yards before leaving in the third quarter, is day-to-day with a rib injury. You can stream Chargers vs Bills live on FOX One. FOX One brings together live FOX NFL games, highlights, expert coverage, and live and on-demand FOX programming, all in one place. Start your 3-day free trial and stream on supported devices.

FOX + ESPN NFL Schedule 2026 — Week 3

Sunday, September 27, 2026
Week 3 — Watch Panthers vs Browns — 1:00 p.m. ET / 10:00 a.m. PT
Week 3 — Watch Chargers vs Bills — 1:00 p.m. ET / 10:00 a.m. PT
Week 3 — Watch Jets vs Lions — 1:00 p.m. ET / 10:00 a.m. PT
Week 3 — Watch Seahawks vs Commanders — 1:00 p.m. ET / 10:00 a.m. PT
Week 3 — Watch Cardinals vs 49ers — 4:05 p.m. ET / 1:05 p.m. PT
Week 3 — Watch Vikings vs Buccaneers — 4:05 p.m. ET / 1:05 p.m. PT

Monday, September 28, 2026
Week 3 — Watch Eagles vs Bears — 8:15 p.m. ET / 5:15 p.m. PT

Buffalo won its first league title at the Chargers’ expense, 20-7 in the AFL Championship Game on Dec. 26, 1964 at War Memorial Stadium, then repeated on the same date a year later with a 23-0 shutout in San Diego. The Bills lead the postseason ledger 2-1, the Chargers’ lone win there coming in the AFC Divisional Round on Jan. 3, 1981, 20-14. The regular season reads the other way: the Chargers lead it 24-12-2 going back to the AFL’s first year, 1960.