Buffalo beat the Los Angeles Chargers 24-16. James Cook III ran for 154 yards and a touchdown despite five Bills turnovers.
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Highmark Stadium
5:00 PM Sunday, September 27, 2026
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The final score was Bills 24, Chargers 16. Los Angeles led 13-10 entering the fourth quarter before touchdown runs by Josh Allen and Cook gave Buffalo the lead at Highmark Stadium in Orchard Park. The Bills moved to 3-0.
Allen threw for 204 yards and ran for two touchdowns, Greg Rousseau had two sacks, and Justin Herbert threw for 226 yards and a touchdown for Los Angeles. Cameron Dicker kicked three field goals. FOX One brings together live FOX NFL games, highlights, expert coverage, and live and on-demand FOX programming in one place. Start your 3-day free trial and stream on supported devices.
Chargers vs Bills aired on FOX on Sunday, Sept. 27, 2026 at 1:00 p.m. ET / 10:00 a.m. PT from Highmark Stadium in Orchard Park, NY in Week 3 of the 2026 NFL season.
Yes. The full replay of Chargers vs Bills and its highlights are available on FOX One.
Buffalo beat the Chargers 24-16. James Cook III ran for 154 yards and a touchdown, and the Bills won despite five turnovers. Watch Los Angeles Chargers vs Buffalo Bills highlights or stream on FOX One. The Week 3 game of the 2026 NFL season came from Highmark Stadium in Orchard Park, NY on Sunday, Sept. 27, 2026 at 1:00 p.m. ET / 10:00 a.m. PT.
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Buffalo won its first league title at the Chargers' expense, 20-7 in the AFL Championship Game on Dec. 26, 1964 at War Memorial Stadium, then repeated on the same date a year later with a 23-0 shutout in San Diego. The Bills lead the postseason ledger 2-1, the Chargers' lone win there coming in the AFC Divisional Round on Jan. 3, 1981, 20-14. The regular season reads the other way: the Chargers lead it 24-13-2 going back to the AFL's first year, 1960.