In a two-hour special, Anthony Anderson gathers male celebrities, including Taye Diggs, Tyler Posey, and James Van Der Beek, to strip away the stigma around men's cancers. They rehearse for a daring strip-tease dance, crafted by Mandy Moore, in front of a live audience. Alongside rehearsals, they share personal cancer stories, expand limits, test modesty, and form a brotherhood.