David Ortiz discusses the significant increase in pitching velocity in modern baseball, where pitchers like Jacob Misiorowski are consistently throwing over 100 MPH. He explains the immense challenge this presents for hitters, emphasizing how even a small increase in velocity makes a significant difference at the plate. Ortiz comically states that if the game starts at 7 PM, hitters need to start swinging at 7 AM to catch up to such speed, and details the specific pitches that are particularly difficult to hit.