The San Francisco 49ers defeated the depleted Los Angeles Chargers by a final score of 22-16. Jimmy Garoppolo went 19-of-28 for 240 yards, a rushing touchdown and 94.3 passer rating. The 49ers' defense came up big, intercepting Justin Herbert's late fourth-quarter pass during the Chargers' final drive. Watch as Colin Cowherd explains why he believes the 49ers need to 'let Jimmy G rip it' more.