Taub and Chase explain to Frankie and Taylor that she can have a replacement made out of plastic that may cause birth defects or a replacement pig's heart, which will last only ten years. Frankie turns to her blog to get input from her readers. This hurts Taylor.

Wilson walks into his office and finds posters of "Feral Pleasures" have replaced his art. Even the cashier in the cafeteria comments about Wilson's movie. He asks Chase for any dirt on House he can use in retaliation. Chase knows that House is reading a Henry James book that should be a lot thicker than the one he is always digging into. Plus, House never wears his glasses when reading it. He must be hiding another book inside of the cover that he doesn't want anyone to know about. Wilson and Chase go through House's office and find the book. It is actually sermons written by a minister.

Frankie chooses the plastic valve, and Taylor is not happy about her connection to the attention she gets on the internet. Frankie suffers a sudden abdomen pain. After surgery, Foreman and Chase tell her that they removed her appendix after it burst. It was filled with abnormal cells that indicate lymphoma. The cells spread through her body when the appendix burst. She has been approved for an experimental treatment that will create a vaccine to kill the bad cells. She has a year to live. Frankie immediately thinks about the impact on her blog.

Chase is shocked that people treat him differently because of his looks. Thirteen advises him to just take people at face value for being nice. Meanwhile, House finds Wilson reading the book when he comes home. Wilson presses him about why he is reading a religious book that he knows House thinks is nonsense. The next day, House walks into his office to find the entire team with copies of the sermon book. He is alarmed to learn that Chase called the author to get the copies.

The vaccine tricked Frankie's immune response and she incurs a high fever. House wonders why Frankie would be able to sleep in a hospital during the day. Chase notes that she is a night owl.  House checks the times of Frankie's online posts. At some point she switched from writing in the day to the night. This reversal is a sign of liver disease, so she must not actually have lymphoma. Chase and Foreman break the news to Frankie that she really only has days to live. The team tries to solve the case before it is too late. They have to find something unique about her infection.

Wilson recognizes the author of the sermons as House's biological father. He wonders why he doesn't just contact him. House says he was only curious but Wilson can't fathom why House would bother with something he thinks is crap. The word "crap" triggers an idea in House. He rushes to Frankie's bed and inquires about her bowel movements, which changed a few months ago. The one thing she wasn't open about in her blog. She has a GI infection that causes malabsorption called Whipple's disease. Taylor will still need a new heart valve but she is going to survive. Frankie decides to go with the pig valve and Taylor brings her laptop over so she can write about it.

Chase wonders whether people can know each other over the internet compared with face-to-face. Thirteen realizes that his interest in the subject is really about his breakup with Cameron. She tells him not to be paranoid that their relationship wasn't real.

Wilson admits that he realizes House was trying to find some sort of connection with his father's mind in order to understand himself. Maybe there was another person like him out there. Meanwhile, Cuddy orders the giant poster of "Feral Pleasures" above the door to be taken down.